If an immune cell recognises foreign matter, it can present it to another immune cell. In this way, activation of T-cells may be induced or slowed down, which could be used for improved management of acute or chronic infections, improved results from vaccination or prevention of autoimmune diseases. To do this, T-cells make contact with the antigen-presenting immune cells and read information from their surface. Helmholtz - Gemeinschaft Deutscher Forschungszentren. Third party content and cookies e.
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This cell type is responsible for classifying the presented parts as dangerous or harmless and, if necessary, initiating a response against them. Please find more information in our privacy statement.
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The ring pattern is thus a result of mechanical forces in the cell membrane which sorts the molecules in the synapse according to their size. An important milestone in the short term is the proper production of the cells following defined standards of Good Manufacturing Practice GMP. You can personalize your cookie settings here:. Dustin to simulate the formation of synapses using computer models.
If all the components of the synapse are correctly positioned, activation of the immune cell will result.
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|In this way, activation of T-cells may be induced or slowed down, which could be used for improved management of acute or chronic infections, improved results from vaccination or prevention of autoimmune diseases.
More information in German on this topic at: Anastasios Siokis, Philippe A. We use different types of cookies. Necessary cookies Only cookies permitted that are required for the basic functionality of our websites.
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To do this, T-cells make contact with the antigen-presenting immune cells and read information from their surface.
They organise themselves in small clusters which are transported by actin in the direction of the centre of the synapse. These tasks are shared among different cell types: From a medical point of view, these results are of particular significance for the area of treatment of defective T-cell activity.
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Microscope image shows an immunological synapse. Different immune cells are therefore constantly in search of foreign molecules indicating the presence of any pathogen which needs to be destroyed.
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An important milestone in the short term is the proper production of the cells following defined standards of Good Manufacturing Practice GMP.
Helmholtz - Gemeinschaft Deutscher Forschungszentren. This setting enables the full use of our web services e. Contact for the media. T-cells red and B-cells blue form immunological synapses at their contact point green. From a medical point of view, these results are of particular significance for the area of treatment of defective T-cell activity.
More information in German on this topic at:
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|Involved Groups Systems Immunology.
The loose bond formed between the two cell surfaces allows for the binding of T-cell receptors to the presented antigen.
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